Effects of ovariectomy and 17β-estradiol treatment on the renin–angiotensin system, blood pressure, and endothelial ultrastructure
X Xu, JC Xiao, LF Luo, S Wang, JP Zhang… - International journal of …, 2008 - Elsevier
The purpose of this study was to determine whether the renin–angiotensin system (RAS),
nitric oxide (NO), atrial natriuretic peptide (ANP), blood pressure (BP), ultrastructural
characteristics, and endothelium-dependent relaxation of thoracic aorta were modulated by
the estrogen level. Rats were divided into 3 groups: ovariectomized (OVX); not
ovariectomized (sham); and ovariectomized and treated with subcutaneous 17β-estradiol
(15 μg/kg/day, OVX+ E2)(n= 15–17 per group). For 13 weeks after surgery, blood pressure …
nitric oxide (NO), atrial natriuretic peptide (ANP), blood pressure (BP), ultrastructural
characteristics, and endothelium-dependent relaxation of thoracic aorta were modulated by
the estrogen level. Rats were divided into 3 groups: ovariectomized (OVX); not
ovariectomized (sham); and ovariectomized and treated with subcutaneous 17β-estradiol
(15 μg/kg/day, OVX+ E2)(n= 15–17 per group). For 13 weeks after surgery, blood pressure …
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